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Join Us69. Zhijun Zhou+, Yang Ke+, Rui Miao, Fen Hu, Xiaoqin Wang, Yuanyuan Ping*, Sheng Xu & Wangqing Kong*. Direct stereoselective C(sp3)-H alkylation of saturated heterocycles using olefins. Nat. Chem. 2025, 17, 344-355. (highlighted by Nat. Chem. 2025, 17, 309-310.)
68. Yongli Liu, Yuanyuan Ping*, Wangqing Kong*. Nickel-Catalyzed Ligand-Controlled Switchable Skeletal Rearrangements: Divergent Synthesis of Isoquinoline-1,3-diones, Cyclohexenols, Cycloheptenols, and 2-Benzazepin-5-ones. SCIENCE CHINA Chemistry 2024, DOI: 10.1007/s11426-024-2485-3.
67. Sheng Xu+, Yuanyuan Ping+, Yinyan Su+, Haoyun Guo, Aowei Luo & Wangqing Kong*. A modular approach to catalytic stereoselective synthesis of chiral 1,2-diols and 1,3-diols. Nat. Commun. 2025, 16, 364-377.
66. Sheng Xu+, Yuanyuan Ping+, Minghao Xu, Guozhen Wu, Yang Ke, Rui Miao, Xiaotian Qi*, Wangqing Kong*. Stereoselective and site-divergent synthesis of C-glycosides. Nat. Chem. 2024, 16, 2054-2065.
65. Shengwei Hu+, Xiaoqin Wang+, Tianbao Wu+, Zhengtian Ding, Minyan Wang*, Wangqing Kong*. Ni-Catalyzed
Enantioselective Reductive Cyclization/Amidation and Amination of 1,6-Enynes
and 1,7-Enynes. Angew. Chem.
Int. Ed. 2025, 64, e202413892.
64. Qi Pan+, Kuai Wang+, Weipeng Xu+, Yuqi Ai, Yuanyuan Ping, Chuhan Liu, Minyan Wang*, Junliang Zhang*, and Wangqing Kong*. Ligand-Controlled, Nickel-Catalyzed Stereodivergent Construction of 1,3-Nonadjacent Stereocenters. J. Am. Chem. Soc. 2024, 146, 15453-15463.
63. Wenfeng Liu+, Wei Li+, Weipeng Xu, Minyan Wang*, and Wangqing Kong* Nickel-catalyzed switchable arylative/endo cyclization of 1,6-enynes. Nat. Commun. 2024, 15, 2914.
62. Wenfeng Liu+, Yunxin Xing+, Denghong Yan+, Wangqing Kong*, and Kun Shen*. Nickel-Catalyzed Electrophiles-Controlled Enantioselective Reductive Arylative Cyclization and Enantiospecific Reductive Alkylative Cyclization of 1,6-Enynes. Nat. Commun. 2024, 15, 1787.
61. Kuai Wang* and Wangqing Kong*. Synthesis of Fluorinated Compounds by Nickel-Catalyzed Defluorinative Cross-Coupling Reactions. ACS Catal. 2023, 13, 12238-12268.
60. Wenfeng Liu and Wangqing Kong. Reduction:
reductive coupling with C-X (X = halogen, O, N) bond dissociation. Comprehensive
Chirality, 2nd edition. DOI:
10.1016/B978-0-32-390644-9.00036-6.
59. Sheng Xu, Yuanyuan Ping, Wei Li, Haoyun Guo, Yinyan Su, Ziyang Li, Minyan Wang*, and Wangqing Kong*. Enantioselective C(sp3)–H Functionalization of Oxacycles via Photo-HAT/Nickel Dual Catalysis. J. Am. Chem. Soc. 2023, 145, 9, 5231-5241.
58. Yang Ke, Wei Li, Wenfeng Liu, Wangqing Kong*. Ni-Catalyzed Ligand-Controlled Divergent and Selective Synthesis. SCIENCE CHINA Chemistry, 2023, 66, 2951-2976.
57. Qi Pan, Yuanyuan Ping, and Wangqing Kong*. Nickel-Catalyzed Ligand-Controlled Selective Reductive Cyclization/Cross-Couplings. Acc. Chem. Res. 2023, 56, 5, 515–535. (Front cover)
56. Yifan Wang, Yuanyuan Ping*, Wangqing Kong*. Synergistic Pd/Cu-catalyzed regio- and stereoselective cascade Heck cyclization/borylation/cross-coupling. Chinese Chemical Letters 2023, 34, 108453.
55. Yuanyuan Ping, Haixia Song*, Wangqing Kong*. Recent Advances in Ni-Catalyzed Asymmetric Reductive Difunctionalization of Alkenes. Chin. J. Org. Chem. 2022, 42, 3302-3321. (Review and Progress Articles; Cover Story)
54. Wenfeng Liu,+ Yang Ke,+ Chuhan Liu and Wangqing Kong*. Direct acylation and alkynylation of hydrocarbons via synergistic decatungstate photo-HAT/nickel catalysis. Chem. Commun. 2022, 58, 11937-11940. (Invited contribution for ChemComm "Emerging Investigators 2022" themed issue)
52. Teng Ma, Xiao Li, Yuanyuan Ping*, Wangqing Kong*. Synthesis of gem-Difluoroalkenes via Ni-Catalyzed Three-Component Defluorinative Reductive Cross-Coupling of Organohalides, Alkenes and Trifluoromethyl Alkenes. Chin. J. Chem. 2022, 40, 2212-2218.
50.Yuanyuan Ping,+ Qi Pan,+ Ya Guo, Yongli Liu, Xiao Li, Minyan Wang*, and Wangqing Kong*. Switchable 1,2-Rearrangement Enables Expedient Synthesis of Structurally Diverse Fluorine-Containing Scaffolds. J. Am. Chem. Soc. 2022, 144, 26, 11626–11637 (Front Cover)
49.Yuanyuan Ping,+ Xiao Li,+ Qi Pan,+ Wangqing Kong*. Ni-Catalyzed Divergent Synthesis of 2-Benzazepine Derivatives via Tunable Cyclization and 1,4-Acyl Transfer Triggered by Amide N-C Bond Cleavage. Angew. Chem. Int. Ed. 2022. 61, e202201574.
48. Hengxu Li + (undergraduate student), Jiachang Chen+, Jueqi Dong (undergraduate student), Wangqing Kong*. Ni-Catalyzed Reductive Arylcyanation of Alkenes. Organic Letters 2021, 23 (16) , 6466-6470.
47. Qi Pan+, Yuanyuan Ping+, Yifan Wang, Ya Guo, and Wangqing Kong*. Ni-Catalyzed Ligand-Controlled Regiodivergent Reductive Dicarbofunctionalization of Alkenes. J. Am. Chem. Soc. 2021, 143, 27, 10282-10291. (Cover Story)
46.Herong chen, Zhijun Zhou and Wangqing Kong*. Allylic Alcohol Synthesis by Ni-Catalyzed Direct and Selective Coupling of Alkynes and Methanol. Chem. Sci. 2021, 12, 9372.
45. Xiao-Wang Chen, Jun-Ping Yue, Kuai Wang, Yong-Yuan Gui, Ya-Nan Niu, Jie Liu, Chuan-Kun Ran, Wangqing Kong*, Wen-Jun Zhou, Da-Gang Yu*. Nickel-Catalyzed Asymmetric Reductive Carbo-Carboxylation of Alkenes with CO2. Angew. Chem. Int. Ed., 2021, 60, 14068-14075
44. Zhengtian Ding, Yiming Wang, Wenfeng Liu, Yate Chen and Wangqing Kong*. Diastereo- and Enantioselective Construction of Spirocycles by Nickel-Catalyzed Cascade Borrowing Hydrogen Cyclization. J. Am. Chem. Soc. 2021, 143, 1, 53–59
43. Sheng Xu, Herong Chen, Zhijun Zhou and Wangqing Kong*. Three-Component Alkene Difunctionalization via Direct and Selective Activation of Aliphatic C-H Bonds.Angew. Chem. Int. Ed., 2021, 60,
7405-7411
42. Yate Chen, Zhengtian Ding, Yiming Wang, Wenfeng Liu and Wangqing Kong*. Synthesis of Indanones and Spiroindanones by Diastereoselective Annulation Based on a Hydrogen Autotransfer Strategy. Angew. Chem. Int. Ed. 2021, 60, 5273 –5278.
41. Wenfeng Liu and Wangqing Kong*. Ni-Catalyzed stereoselective difunctionalization of alkynes. Org. Chem. Front., 2020, 7: 3941-3955. (Invited Review)
40. Baihang Ju and Wangqing Kong*. Recent Progress in the Consecutive Double Heck Reaction. Asian J. Org. Chem., 2020, 9: 1154 –1161. (Invited Review)
39. Zhijun Zhou+, Wenfeng Liu+ and Wangqing Kong*. Ni-Catalyzed Reductive Antiarylative Cyclization of Alkynones. Org. Lett., 2020, 22: 6982−6987.
38. Zhijun Zhou, Jiachang Chen, Herong Chen and Wangqing Kong*. Stereoselective synthesis of pentasubstituted 1,3-dienes via Ni-catalyzed reductive coupling of unsymmetrical internal alkynes. Chem. Sci., 2020, 11: 10204-10211.
37. Zhijun Zhou, Sheng Xu, Jing Zhang* and Wangqing Kong*. Nickel-catalyzed enantioselective electroreductive cross-couplings. Org. Chem. Front., 2020, 7: 3262-3265.
36. Yuanyuan Ping and Wangqing Kong*. Ni-Catalyzed Reductive Difunctionalization of Alkenes. Synthesis, 2020, 52: 979–992. (Invited Review)
35. Jiachang Chen, Yiming Wang, Zhengtian Ding, and Wangqing Kong*. Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones. Nat. Commun., 2020, 11, 1882.
34. Baihang Ju, Shigui Chen, Wangqing Kong*. Pd-Catalyzed Enantioselective Double Heck Reaction. Organic Letters 2019 21 (23), 9343-9347
33. Baihang Ju, Shigui Chen, Wangqing Kong*. Enantioselective palladium-catalyzed diarylation of unactivated alkenes. Chem. Commun. 2019, 55, 14311-14314
32.Teng Ma+, Yate Chen+, Yuxiu Li, Yuanyuan Ping and Wangqing Kong*.Nickel-Catalyzed Enantioselective Reductive Aryl Fluoroalkenylation of Alkenes. ACS Catal., 2019, 9, 9127-9133
31. Sheng Xu+, Kuai Wang+ and Wangqing Kong*. Ni-Catalyzed Reductive Arylacylation of Alkenes toward Carbonyl-Containing Oxindoles. Org. Lett., 2019, 21, 7498-7503
30. Yuxiu Li, Zhengtian Ding, Aiwen Lei* and Wangqing Kong*. Ni-Catalyzed enantioselective reductive aryl-alkenylation of alkenes: application to the synthesis of (+)-physovenine and (+)-physostigmine. Org. Chem. Front., 2019, 6, 3305-3309
29. Yuanyuan Ping+, Kuai Wang+, Qi Pan, Zhengtian Ding, Zhijun Zhou, Ya Guo, and Wangqing Kong*. Ni-Catalyzed Regio- and Enantioselective Domino Reductive Cyclization: One-Pot Synthesis of 2,3-Fused Cyclopentannulated Indolines. ACS Catal. 2019, 9, 7335−7342.
28. Kuai Wang and Wangqing Kong*. Enantioselective Reductive Diarylation of Alkenes by Ni-Catalyzed Domino Heck Cyclization/Cross Coupling. Synlett 2019, 23,1103-1107. (Synpact article: invited review highlighting work in pub. 27)
27. Kuai Wang, Zhengtian Ding, Zhijun Zhou, and Wangqing Kong*. Ni-Catalyzed Enantioselective Reductive Diarylation of Activated Alkenes by Domino Cyclization/Cross-Coupling. J. Am. Chem. Soc., 2018, 140, 12364-12368.
26. Yuanyuan Ping+, Yuxiu Li+, Jieping Zhu*, Wangqing Kong*. Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions.Angew. Chem. Int. Ed. 2019, 58: 1562-1573.
25. Yuxiu Li, Kuai Wang, Yuanyuan Ping, Yifan Wang, and Wangqing Kong*. Nickel-Catalyzed Domino Heck Cyclization/Suzuki Coupling for the Synthesis of 3,3-Disubstituted Oxindoles. Org. Lett. 2018, 20, 921−924 (Highlighted by Synfacts, 2018, 14(4), 410)
24. Kuai Wang, Wangqing Kong*. Recent Advances in Transition Metal Catalyzed Asymmetric Radical Reactions. Chin. J. Chem. 2018, 36, 247-256. (Cover Story)
23. Wangqing Kong, Qian Wang, Jieping Zhu*. Water as hydride source in palladium-catalyzed enantioselective reductive Heck reaction. Angew. Chem. Int. Ed. 2017, 56, 3987-3991. (Chosen by the Editors as a “Hot Paper”) (Highlighted by Synfacts, 2017, 13(5), 495) (Highly Cited Paper)
22. Wangqing Kong, Qian Wang, Jieping Zhu*. Switchable synthesis of diversely functionalized oxindoles enabled by migratory insertion of isocyanide to a transient σ-alkylpalladium(II) complex. Angew. Chem. Int. Ed. 2016, 55, 9714-9718.
21. Wangqing Kong, Qian Wang, Jieping Zhu*. Palladium-catalyzed enantioselective domino heck/intermolecular C-H bond functionalization: Development and application to the synthesis of (+)-esermethole. J. Am. Chem. Soc. 2015, 137, 16028-16031. (Highlighted by Synfacts, 2016, 12(3), 274.)
20. Wangqing Kong, Noelia Fuentes, Andres García-Domínguez, Estíbaliz Merino, Cristina Nevado*. Stereoselective synthesis of highly functionalized indanes and dibenzocycloheptadienes via complex radical cascades. Angew. Chem. Int. Ed. 2015, 54, 2487-2491.
19. Noelia Fuentes, Wangqing Kong, Luis Fernández-Sánchez, Estíbaliz Merino, Cristina Nevado*. Cyclization cascades via N-amidyl radicals toward highly functionalized heterocyclic scaffolds. J. Am. Chem. Soc. 2015, 137, 964-973. (Highly Cited Paper)
18. Wangqing Kong, Estíbaliz Merino, Cristina Nevado*. Arylphosphonylation and arylazidation of activated alkenes. Angew. Chem. Int. Ed. 2014, 53, 5078-5082. (Chosen by the Editors as a “Hot Paper”) (Highly Cited Paper)
17. Youai Qiu, Dengke Ma, Wangqing Kong, Chunling Fu, Shengming Ma*. Regiocontrolled 1,2-migration in cyclization of 1-(indol-2-yl)-3-alkyn-1-ols: (Ph3P)Au+ vs. PtCl4. Org. Chem. Front. 2014, 1, 62-67.
16. Wangqing Kong, Estíbaliz Merino, Cristina Nevado*. Divergent reaction mechanism in the aminofluorination of alkenes. CHIMIA International Journal for Chemistry, 2014, 68, 430-435.
15. Wangqing Kong, Maria Casimiro, Noelia Fuentes, Estíbaliz Merino, Cristina Nevado*. Metal-free aryltrifluoromethylation of activated alkenes. Angew. Chem. Int. Ed. 2013, 52, 13086-13090. (Highly Cited Paper)
14. Wangqing Kong, Maria Casimiro, Estibaliz Merino, Cristina Nevado*. Copper-catalyzed 1-pot trifluoromethylation/arylmigration/desulfonylation and Csp2-N bond formation of conjugated tosyl amides. J. Am. Chem. Soc. 2013, 135, 14480-14483. (Highly Cited Paper)
13. Wangqing Kong, Pascal Feige, Teresa de Haro, Cristina Nevado*. Regio- and enantioselective aminofluorination of alkenes. Angew. Chem. Int. Ed. 2013, 52, 2469-2473. (Highlighted by Synfacts 2013, 9 (4), 371 and Organic Chemistry Portal 2014, March 17.) (Highly Cited Paper)
12. Youai Qiu, Wangqing Kong, Chunling Fu, Shengming Ma*. Carbazoles via AuCl3-catalyzed cyclization of 1-(indol-2-yl)-3-alkyn-1-ols. Org. Lett. 2012, 14, 6198-6201.
11. Wangqing Kong, Youai Qiu, Xue Zhang, Chunling Fu, Shengming Ma*. Exclusive 1,2-aryl shift in Platinum(II) chloride-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols. Adv. Synth. Catal. 2012, 354, 2339-2347.
10. Wangqing Kong, Chunling Fu, Shengming Ma*. Efficient synthesis of carbazoles via PtCl2-catalyzed RT cyclization of 1-(indol-2-yl)-2,3-allenols: scope and mechanism. Org. Biomol. Chem. 2012, 10, 2164-2173.
9. Wangqing Kong, Chunling Fu, Shengming Ma*. General Au-catalyzed benzannulation towards naturally occurring carbazole alkaloids from methoxypropadiene. Chem. Eur. J. 2011, 17, 13134-13137.
8. Wangqing Kong, Binjie Guo, Chunling Fu, Shengming Ma*. An efficient approach to 2-bromoalken-3-ols by regioselective bromohydroxylation reaction of simple allenes with NBS. Eur. J. Org. Chem. 2011, 2278-2285.
7. Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient synthesis of polysubstituted naphthalene derivatives by gold-catalyzed cyclization of 1-arylalka-2,3-dienyl acetates. Eur. J. Org. Chem. 2010, 6545-6555.(Cover Story)
6. Jing Li, Wangqing Kong, Yihua Yu, Chunling Fu, Shengming Ma*. Studies on electrophilic reaction of tertiary 2,3-allenols with NBS in H2O or aqueous MeCN: an efficient selective Synthesis of 2-bromoallylic ketones, 1,2-allenyl ketones, or 3-bromo-2,5-dihydrofurans. J. Org. Chem. 2009, 74, 8733–8738.
5. Jing Li, Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient CuCN-catalyzed synthesis of optically active 2,3-allenols from optically active 1-substituted 4-chloro-2-butyn-1-ols. J. Org. Chem. 2009, 74, 5104–5106.
4. Wangqing Kong, Jie Cui, Yihua Yu, Guofei Chen, Chunling Fu, Shengming Ma*. PtCl4-catalyzed cyclization reaction of β-allenols in the presence of indole. Org. Lett. 2009, 11, 1213-1216.
3. Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient synthesis of carbazoles from PtCl2-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols. Chem. Commun. 2009, 4572–4574.
2. Xuefeng Jiang, Wangqing Kong, Jie Chen, Shengming Ma*. Intermolecular sequential [4+2]-cycloaddition–aromatization reaction of aryl-substituted allenes with DMAD affording phenanthrene and naphthalene derivatives. Org. Biomol. Chem. 2008, 6, 3606–3610.
1. Wangqing Kong, Chunling Fu, Shengming Ma*. Indium and zinc-mediated Barbier-type addition reaction of 2,3-allenals with allyl bromide: an efficient synthesis of 1,5,6-alkatrien-4-ols. Org. Biomol. Chem. 2008, 6, 4587–4592.