The Center for Precision Synthesis, Institute

for Advanced Studies, Wuhan University

Recent Publications


69. Zhijun Zhou+, Yang Ke+, Rui Miao, Fen Hu, Xiaoqin Wang, Yuanyuan Ping*, Sheng Xu & Wangqing Kong*. Direct stereoselective C(sp3)-H alkylation of saturated heterocycles using olefins. Nat. Chem. 2025, 17, 344-355. (highlighted by Nat. Chem. 2025, 17, 309-310.)



68. Yongli Liu, Yuanyuan Ping*, Wangqing Kong*. Nickel-Catalyzed Ligand-Controlled Switchable Skeletal Rearrangements: Divergent Synthesis of Isoquinoline-1,3-diones, Cyclohexenols, Cycloheptenols, and 2-Benzazepin-5-ones. SCIENCE CHINA Chemistry 2024, DOI: 10.1007/s11426-024-2485-3.



67. Sheng Xu+, Yuanyuan Ping+, Yinyan Su+, Haoyun Guo, Aowei Luo & Wangqing Kong*. A modular approach to catalytic stereoselective synthesis of chiral 1,2-diols and 1,3-diols. Nat. Commun. 2025, 16, 364-377.



66. Sheng Xu+, Yuanyuan Ping+, Minghao Xu, Guozhen Wu, Yang Ke, Rui Miao, Xiaotian Qi*, Wangqing Kong*. Stereoselective and site-divergent synthesis of C-glycosides. Nat. Chem. 2024, 16, 2054-2065.


65. Shengwei Hu+, Xiaoqin Wang+, Tianbao Wu+, Zhengtian Ding, Minyan Wang*, Wangqing Kong*. Ni-Catalyzed Enantioselective Reductive Cyclization/Amidation and Amination of 1,6-Enynes and 1,7-Enynes. Angew. Chem. Int. Ed. 2025, 64, e202413892.





64. Qi Pan+, Kuai Wang+, Weipeng Xu+, Yuqi Ai, Yuanyuan Ping, Chuhan Liu, Minyan Wang*, Junliang Zhang*, and Wangqing Kong*. Ligand-Controlled, Nickel-Catalyzed Stereodivergent Construction of 1,3-Nonadjacent Stereocenters. J. Am. Chem. Soc. 2024, 146, 15453-15463.




63. Wenfeng Liu+, Wei Li+, Weipeng Xu, Minyan Wang*, and Wangqing Kong* Nickel-catalyzed switchable arylative/endo cyclization of 1,6-enynes. Nat. Commun. 2024, 15, 2914.




62. Wenfeng Liu+, Yunxin Xing+, Denghong Yan+, Wangqing Kong*, and Kun Shen*. Nickel-Catalyzed Electrophiles-Controlled Enantioselective Reductive Arylative Cyclization and Enantiospecific Reductive Alkylative Cyclization of 1,6-Enynes. Nat. Commun. 2024, 15, 1787.




61. Kuai Wang* and Wangqing Kong*. Synthesis of Fluorinated Compounds by Nickel-Catalyzed Defluorinative Cross-Coupling Reactions. ACS Catal. 2023, 13, 12238-12268.




60. Wenfeng Liu and Wangqing Kong. Reduction: reductive coupling with C-X (X = halogen, O, N) bond dissociation. Comprehensive Chirality, 2nd edition. DOI: 10.1016/B978-0-32-390644-9.00036-6.





59. Sheng Xu, Yuanyuan Ping, Wei Li, Haoyun Guo, Yinyan Su, Ziyang Li, Minyan Wang*, and Wangqing Kong*. Enantioselective C(sp3)–H Functionalization of Oxacycles via Photo-HAT/Nickel Dual Catalysis. J. Am. Chem. Soc. 2023, 145, 9, 5231-5241.






58. Yang Ke, Wei Li, Wenfeng Liu, Wangqing Kong*. Ni-Catalyzed Ligand-Controlled Divergent and Selective Synthesis. SCIENCE CHINA Chemistry, 2023, 66, 2951-2976.




57. Qi Pan, Yuanyuan Ping, and Wangqing Kong*. Nickel-Catalyzed Ligand-Controlled Selective Reductive Cyclization/Cross-Couplings. Acc. Chem. Res. 202356, 5, 515–535. (Front cover)




56. Yifan Wang, Yuanyuan Ping*, Wangqing Kong*. Synergistic Pd/Cu-catalyzed regio- and stereoselective cascade Heck cyclization/borylation/cross-coupling. Chinese Chemical Letters  202334, 108453.



55. Yuanyuan Ping, Haixia Song*, Wangqing Kong*. Recent Advances in Ni-Catalyzed Asymmetric Reductive Difunctionalization of Alkenes. Chin. J. Org. Chem. 2022, 42, 3302-3321. (Review and Progress Articles; Cover Story)



54. Wenfeng Liu,+ Yang Ke,+ Chuhan Liu and Wangqing Kong*. Direct acylation and alkynylation of hydrocarbons via synergistic decatungstate photo-HAT/nickel catalysis. Chem. Commun. 2022, 58, 11937-11940. (Invited contribution for ChemComm "Emerging Investigators 2022" themed issue)




53. Kuai Wang+, Jiachang Chen+, Wenfeng Liu+, Wangqing Kong*. Nickel-Catalyzed Defluorinative Asymmetric Cyclization of Fluoroalkyl-Substituted 1,6-Enynes for the Synthesis of Seletracetam. Angew. Chem. Int. Ed. 202261, e202212664.



52. Teng Ma, Xiao Li, Yuanyuan Ping*, Wangqing Kong*. Synthesis of gem-Difluoroalkenes via Ni-Catalyzed Three-Component Defluorinative Reductive Cross-Coupling of Organohalides, Alkenes and Trifluoromethyl Alkenes. Chin. J. Chem. 2022, 40, 2212-2218.




51. Wenfeng Liu+, Chuhan Liu+, Minyan Wang*, and Wangqing Kong*. Modular Synthesis of Multifunctionalized CF3-Allenes through Selective Activation of Saturated Hydrocarbons. ACS Catal. 2022, 12, 16, 10207–10221. (Front cover)




50.Yuanyuan Ping,+ Qi Pan,Ya Guo, Yongli Liu, Xiao Li, Minyan Wang*, and Wangqing Kong*. Switchable 1,2-Rearrangement Enables Expedient Synthesis of Structurally Diverse Fluorine-Containing Scaffolds. J. Am. Chem. Soc. 2022, 144, 26, 11626–11637 (Front Cover)




49.Yuanyuan Ping,+ Xiao Li,+ Qi Pan,+ Wangqing Kong*. Ni-Catalyzed Divergent Synthesis of 2-Benzazepine Derivatives via Tunable Cyclization and 1,4-Acyl Transfer Triggered by Amide N-C Bond CleavageAngew. Chem. Int. Ed. 2022. 61, e202201574.




48. Hengxu Li + (undergraduate student), Jiachang Chen+, Jueqi Dong (undergraduate student), Wangqing Kong*. Ni-Catalyzed Reductive Arylcyanation of Alkenes.  Organic Letters 2021, 23 (16) , 6466-6470.  




47. Qi Pan+, Yuanyuan Ping+, Yifan Wang, Ya Guo, and Wangqing Kong*. Ni-Catalyzed Ligand-Controlled Regiodivergent Reductive Dicarbofunctionalization of Alkenes. J. Am. Chem. Soc. 2021, 143, 27, 10282-10291. (Cover Story)




46.Herong chen, Zhijun Zhou and Wangqing Kong*. Allylic Alcohol Synthesis by Ni-Catalyzed Direct and Selective Coupling of Alkynes and Methanol. Chem. Sci. 2021, 12, 9372.



45. Xiao-Wang Chen, Jun-Ping Yue, Kuai Wang, Yong-Yuan Gui, Ya-Nan Niu, Jie Liu, Chuan-Kun Ran, Wangqing Kong*, Wen-Jun Zhou, Da-Gang Yu*. Nickel-Catalyzed Asymmetric Reductive Carbo-Carboxylation of Alkenes with CO2Angew. Chem. Int. Ed.202160,  14068-14075



44. Zhengtian Ding, Yiming Wang, Wenfeng Liu, Yate Chen and Wangqing Kong*.  Diastereo- and Enantioselective Construction of Spirocycles by Nickel-Catalyzed Cascade Borrowing Hydrogen Cyclization.  J. Am. Chem. Soc. 2021143, 1, 53–59




43. Sheng Xu, Herong Chen, Zhijun Zhou and Wangqing Kong*.  Three-Component Alkene Difunctionalization via Direct and Selective Activation of Aliphatic C-H Bonds.Angew. Chem. Int. Ed., 2021, 60, 7405-7411



42. Yate Chen, Zhengtian Ding, Yiming Wang, Wenfeng Liu and Wangqing Kong*. Synthesis of Indanones and Spiroindanones by Diastereoselective Annulation Based on a Hydrogen Autotransfer Strategy. Angew. Chem. Int. Ed. 2021605273 –5278.



41. Wenfeng Liu and Wangqing Kong*. Ni-Catalyzed stereoselective difunctionalization of alkynes. Org. Chem. Front., 2020, 7: 3941-3955. (Invited Review)





40. Baihang Ju and Wangqing Kong*. Recent Progress in the Consecutive Double Heck Reaction. Asian J. Org. Chem., 2020, 9: 1154 –1161. (Invited Review)




39. Zhijun Zhou+, Wenfeng Liu+ and Wangqing Kong*. Ni-Catalyzed Reductive Antiarylative Cyclization of Alkynones. Org. Lett., 2020, 22: 69826987.



38. Zhijun Zhou, Jiachang Chen, Herong Chen and Wangqing Kong*. Stereoselective synthesis of pentasubstituted 1,3-dienes via Ni-catalyzed reductive coupling of unsymmetrical internal alkynes. Chem. Sci., 2020, 11: 10204-10211.



37. Zhijun Zhou, Sheng Xu, Jing Zhang* and Wangqing Kong*. Nickel-catalyzed enantioselective electroreductive cross-couplings. Org. Chem. Front., 2020, 7: 3262-3265.



36. Yuanyuan Ping and Wangqing Kong*. Ni-Catalyzed Reductive Difunctionalization of Alkenes. Synthesis, 2020, 52: 979–992. (Invited Review)




35. Jiachang Chen, Yiming Wang, Zhengtian Ding, and Wangqing Kong*. Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones. Nat. Commun., 2020, 11, 1882.



34. Baihang Ju, Shigui Chen, Wangqing Kong*. Pd-Catalyzed Enantioselective Double Heck Reaction. Organic Letters 2019 21 (23), 9343-9347




33. Baihang Ju, Shigui Chen, Wangqing Kong*. Enantioselective palladium-catalyzed diarylation of unactivated alkenes. Chem. Commun. 2019, 55, 14311-14314



32.Teng Ma+, Yate Chen+, Yuxiu Li, Yuanyuan Ping and Wangqing Kong*.Nickel-Catalyzed Enantioselective Reductive Aryl Fluoroalkenylation of Alkenes. ACS Catal., 2019, 9, 9127-9133



31. Sheng Xu+, Kuai Wang+ and Wangqing Kong*. Ni-Catalyzed Reductive Arylacylation of Alkenes toward Carbonyl-Containing Oxindoles. Org. Lett., 2019, 21, 7498-7503




30. Yuxiu Li, Zhengtian Ding, Aiwen Lei* and Wangqing Kong*. Ni-Catalyzed enantioselective reductive aryl-alkenylation of alkenes: application to the synthesis of (+)-physovenine and (+)-physostigmine. Org. Chem. Front., 2019, 6, 3305-3309




29. Yuanyuan Ping+, Kuai Wang+, Qi Pan, Zhengtian Ding, Zhijun Zhou, Ya Guo, and Wangqing Kong*. Ni-Catalyzed Regio- and Enantioselective Domino Reductive Cyclization: One-Pot Synthesis of 2,3-Fused Cyclopentannulated Indolines. ACS Catal. 2019, 9, 7335−7342.





28. Kuai Wang and Wangqing Kong*. Enantioselective Reductive Diarylation of Alkenes by Ni-Catalyzed Domino Heck Cyclization/Cross Coupling. Synlett 2019, 23,1103-1107. (Synpact article: invited review highlighting work in pub. 27)



27. Kuai Wang, Zhengtian Ding, Zhijun Zhou, and Wangqing Kong*. Ni-Catalyzed Enantioselective Reductive Diarylation of Activated Alkenes by Domino Cyclization/Cross-Coupling. J. Am. Chem. Soc., 2018, 140, 12364-12368.





26. Yuanyuan Ping+, Yuxiu Li+, Jieping Zhu*, Wangqing Kong*. Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions.Angew. Chem. Int. Ed. 2019, 58: 1562-1573.



25. Yuxiu Li, Kuai Wang, Yuanyuan Ping, Yifan Wang, and Wangqing Kong*. Nickel-Catalyzed Domino Heck Cyclization/Suzuki Coupling for the Synthesis of 3,3-Disubstituted Oxindoles. Org. Lett. 2018, 20, 921−924 (Highlighted by Synfacts, 2018, 14(4), 410)




24. Kuai Wang, Wangqing Kong*. Recent Advances in Transition Metal Catalyzed Asymmetric Radical Reactions. Chin. J. Chem. 2018, 36, 247-256. (Cover Story)