The Center for Precision Synthesis, Institute

for Advanced Studies, Wuhan University


44. Zhengtian Ding, Yiming Wang, Wenfeng Liu, Yate Chen and Wangqing Kong*.  Diastereo- and Enantioselective Construction of Spirocycles by Nickel-Catalyzed Cascade Borrowing Hydrogen Cyclization. J. Am. Chem. Soc. 2021, 143, 1, 53–59

43. Sheng Xu, Herong Chen, Zhijun Zhou and Wangqing Kong*.  Three-Component Alkene Difunctionalization via Direct and Selective Activation of Aliphatic C-H Bonds. Angew. Chem. Int. Ed. (in press). DOI: 10.1002/anie.202014632.

42.  Yate Chen, Zhengtian Ding, Yiming Wang, Wenfeng Liu and Wangqing Kong*. Synthesis of Indanones and Spiroindanones by Diastereoselective Annulation Based on a Hydrogen Autotransfer Strategy. Angew. Chem. Int. Ed. 2021, 60, 5273 –5278.

41. Wenfeng Liu and Wangqing Kong*. Ni-Catalyzed stereoselective difunctionalization of alkynes. Org. Chem. Front., 2020, 7: 3941-3955. (Invited Review)

40Baihang Ju and Wangqing Kong*. Recent Progress in the Consecutive Double Heck Reaction. Asian J. Org. Chem., 2020, 9: 1154 –1161. (Invited Review)

39. Zhijun Zhou, Wenfeng Liu and Wangqing Kong*. Ni-Catalyzed Reductive Antiarylative Cyclization of Alkynones. Org. Lett., 2020, 22: 69826987.

38. Zhijun Zhou, Jiachang Chen, Herong Chen and Wangqing Kong*. Stereoselective synthesis of pentasubstituted 1,3-dienes via Ni-catalyzed reductive coupling of unsymmetrical internal alkynes. Chem. Sci., 2020, 11: 10204-10211.

37. Zhijun Zhou, Sheng Xu, Jing Zhang* and Wangqing Kong*. Nickel-catalyzed enantioselective electroreductive cross-couplings. Org. Chem. Front., 2020, 7: 3262-3265.

36. Yuanyuan Ping and Wangqing Kong*. Ni-Catalyzed Reductive Difunctionalization of Alkenes. Synthesis, 2020, 52: 979–992. (Invited Review)

35. Jiachang Chen, Yiming Wang, Zhengtian Ding, and Wangqing Kong*. Synthesis of bridged tricyclo[,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones. Nat. Commun., 2020, 11, 1882.

34. Baihang Ju, Shigui Chen, Wangqing Kong. Pd-Catalyzed Enantioselective Double Heck Reaction. Organic Letters 2019 21 (23), 9343-9347

33. Baihang Ju, Shigui Chen, Wangqing Kong. Enantioselective palladium-catalyzed diarylation of unactivated alkenes. Chem. Commun. 2019, 55, 14311-14314

32.Teng Ma, Yate Chen, Yuxiu Li, Yuanyuan Ping and Wangqing Kong*. Nickel-Catalyzed Enantioselective Reductive Aryl Fluoroalkenylation of Alkenes. ACS Catal., 2019, 9, 9127-9133

31. Sheng Xu, Kuai Wang and Wangqing Kong*. Ni-Catalyzed Reductive Arylacylation of Alkenes toward Carbonyl-Containing Oxindoles. Org. Lett., 2019, 21, 7498-7503

30. Yuxiu Li, Zhengtian Ding, Aiwen Lei* and Wangqing Kong*. Ni-Catalyzed enantioselective reductive aryl-alkenylation of alkenes: application to the synthesis of (+)-physovenine and (+)-physostigmine. Org. Chem. Front., 2019, 6, 3305-3309

29. Yuanyuan Ping, Kuai Wang, Qi Pan, Zhengtian Ding, Zhijun Zhou, Ya Guo, and Wangqing Kong*. Ni-Catalyzed Regio- and Enantioselective Domino Reductive Cyclization: One-Pot Synthesis of 2,3-Fused Cyclopentannulated Indolines. ACS Catal. 2019, 9, 7335−7342.


28. Kuai Wang and Wangqing Kong*. Enantioselective Reductive Diarylation of Alkenes by Ni-Catalyzed Domino Heck Cyclization/Cross Coupling. Synlett 2019, 23,1103-1107. (Synpact article: invited review highlighting work in pub. 27)

27. Kuai Wang, Zhengtian Ding, Zhijun Zhou, and Wangqing Kong*. Ni-Catalyzed Enantioselective Reductive Diarylation of Activated Alkenes by Domino Cyclization/Cross-Coupling. J. Am. Chem. Soc., 2018, 140, 12364-12368.

26. Yuanyuan Ping, Yuxiu Li, Jieping Zhu*, Wangqing Kong*. Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions.Angew. Chem. Int. Ed. 2019, 58: 1562-1573.

25. Yuxiu Li, Kuai Wang, Yuanyuan Ping, Yifan Wang, and Wangqing Kong*. Nickel-Catalyzed Domino Heck Cyclization/Suzuki Coupling for the Synthesis of 3,3-Disubstituted Oxindoles. Org. Lett. 2018, 20, 921−924 (Highlighted by Synfacts, 2018, 14(4), 410)

24. Kuai Wang, Wangqing Kong*. Recent Advances in Transition Metal Catalyzed Asymmetric Radical Reactions. Chin. J. Chem. 2018, 36, 247-256. (Cover Story)

Before independent work:

23. Wangqing Kong, Qian Wang, Jieping Zhu*. Water as hydride source in palladium-catalyzed enantioselective reductive Heck reaction. Angew. Chem. Int. Ed. 2017, 56, 3987-3991. (Chosen by the Editors as a “Hot Paper”) (Highlighted by Synfacts, 2017, 13(5), 495) (Highly Cited Paper)

22. Wangqing Kong, Qian Wang, Jieping Zhu*. Switchable synthesis of diversely functionalized oxindoles enabled by migratory insertion of isocyanide to a transient σ-alkylpalladium(II) complex. Angew. Chem. Int. Ed. 2016, 55, 9714-9718.

21. Wangqing Kong, Qian Wang, Jieping Zhu*. Palladium-catalyzed enantioselective domino heck/intermolecular C-H bond functionalization: Development and application to the synthesis of (+)-esermethole. J. Am. Chem. Soc. 2015, 137, 16028-16031. (Highlighted by Synfacts, 2016, 12(3), 274.)

20. Wangqing Kong, Noelia Fuentes, Andres García-Domínguez, Estíbaliz Merino, Cristina Nevado*. Stereoselective synthesis of highly functionalized indanes and dibenzocycloheptadienes via complex radical cascades. Angew. Chem. Int. Ed. 2015, 54, 2487-2491.

19. Noelia Fuentes, Wangqing Kong, Luis Fernández-Sánchez, Estíbaliz Merino, Cristina Nevado*. Cyclization cascades via N-amidyl radicals toward highly functionalized heterocyclic scaffolds. J. Am. Chem. Soc. 2015, 137, 964-973. (Highly Cited Paper)

18. Wangqing Kong, Estíbaliz Merino, Cristina Nevado*. Arylphosphonylation and arylazidation of activated alkenes. Angew. Chem. Int. Ed. 2014, 53, 5078-5082. (Chosen by the Editors as a “Hot Paper”) (Highly Cited Paper)

17. Youai Qiu, Dengke Ma, Wangqing Kong, Chunling Fu,  Shengming Ma*. Regiocontrolled 1,2-migration in cyclization of 1-(indol-2-yl)-3-alkyn-1-ols: (Ph3P)Au+ vs. PtCl4. Org. Chem. Front. 2014, 1, 62-67.

16. Wangqing Kong, Estíbaliz Merino, Cristina Nevado*. Divergent reaction mechanism in the aminofluorination of alkenes. CHIMIA International Journal for Chemistry, 2014, 68, 430-435.

15. Wangqing Kong, Maria Casimiro, Noelia Fuentes, Estíbaliz Merino, Cristina Nevado*. Metal-free aryltrifluoromethylation of activated alkenes. Angew. Chem. Int. Ed. 2013, 52, 13086-13090. (Highly Cited Paper)

14. Wangqing Kong, Maria Casimiro, Estibaliz Merino, Cristina Nevado*. Copper-catalyzed 1-pot trifluoromethylation/arylmigration/desulfonylation and Csp2-N bond formation of conjugated tosyl amides. J. Am. Chem. Soc. 2013, 135, 14480-14483. (Highly Cited Paper)

13. Wangqing Kong, Pascal Feige, Teresa de Haro, Cristina Nevado*. Regio- and enantioselective aminofluorination of alkenes. Angew. Chem. Int. Ed. 2013, 52, 2469-2473. (Highlighted by Synfacts 2013, 9 (4), 371 and Organic Chemistry Portal 2014, March 17.)  (Highly Cited Paper)

12. Youai Qiu, Wangqing Kong, Chunling Fu, Shengming Ma*. Carbazoles via AuCl3-catalyzed cyclization of 1-(indol-2-yl)-3-alkyn-1-ols. Org. Lett. 2012, 14, 6198-6201.

11. Wangqing Kong, Youai Qiu, Xue Zhang, Chunling Fu, Shengming Ma*. Exclusive 1,2-aryl shift in Platinum(II) chloride-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols. Adv. Synth. Catal. 2012, 354, 2339-2347.

10. Wangqing Kong, Chunling Fu, Shengming Ma*. Efficient synthesis of carbazoles via PtCl2-catalyzed RT cyclization of 1-(indol-2-yl)-2,3-allenols: scope and mechanism. Org. Biomol. Chem. 2012, 10, 2164-2173.

9. Wangqing Kong, Chunling Fu, Shengming Ma*. General Au-catalyzed benzannulation towards naturally occurring carbazole alkaloids from methoxypropadiene. Chem. Eur. J. 2011, 17, 13134-13137.

8. Wangqing Kong, Binjie Guo, Chunling Fu, Shengming Ma*. An efficient approach to 2-bromoalken-3-ols by regioselective bromohydroxylation reaction of simple allenes with NBS. Eur. J. Org. Chem. 2011, 2278-2285.

7. Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient synthesis of polysubstituted naphthalene derivatives by gold-catalyzed cyclization of 1-arylalka-2,3-dienyl acetates. Eur. J. Org. Chem. 2010, 6545-6555.(Cover Story)

6. Jing Li, Wangqing Kong, Yihua Yu, Chunling Fu, Shengming Ma*. Studies on electrophilic reaction of tertiary 2,3-allenols with NBS in H2O or aqueous MeCN: an efficient selective Synthesis of 2-bromoallylic ketones, 1,2-allenyl ketones, or 3-bromo-2,5-dihydrofurans. J. Org. Chem. 2009, 74, 8733–8738.

5. Jing Li, Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient CuCN-catalyzed synthesis of optically active 2,3-allenols from optically active 1-substituted 4-chloro-2-butyn-1-ols. J. Org. Chem. 2009, 74, 5104–5106.

4. Wangqing Kong, Jie Cui, Yihua Yu, Guofei Chen, Chunling Fu, Shengming Ma*. PtCl4-catalyzed cyclization reaction of β-allenols in the presence of indole. Org. Lett. 2009, 11, 1213-1216.

3. Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient synthesis of carbazoles from PtCl2-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols. Chem. Commun. 2009, 4572–4574.

2. Xuefeng Jiang, Wangqing Kong, Jie Chen, Shengming Ma*. Intermolecular sequential [4+2]-cycloaddition–aromatization reaction of aryl-substituted allenes with DMAD affording phenanthrene and naphthalene derivatives. Org. Biomol. Chem. 2008, 6, 3606–3610.

1. Wangqing Kong, Chunling Fu, Shengming Ma*. Indium and zinc-mediated Barbier-type addition reaction of 2,3-allenals with allyl bromide: an efficient synthesis of 1,5,6-alkatrien-4-ols. Org. Biomol. Chem. 2008, 6, 4587–4592.